Romuald Corbau
Associate Research Fellow, Pfizer
I obtained a European PhD in Biochemistry in 1998 for my work on the interaction between host cell and the viral life cycle. I joined Pfizer in June 1998 and my initial appointment was in the Anti-infectives department, where I participated in the anti-viral drug discovery programme (HIV and HCV); ultimately leading the programme that resulted in the discovery of UK-453,061 (lersvirine, currently in Phase IIb clinical development). I have worked on all aspect of anti-viral drug discovery from the generation of idea up to phase I clinical trial (FIH), working on both small molecule and biological (antibody and gene therapy). I am currently Associate Research Fellow, where I my main responsibilities consist of the leadership and delivery of a first in patient study (FPFV in 2011). As part of the Internal Medicine Unit leadership team my other responsibilities include scientifically reviewing the portfolio of the department as well as strategically establishing a portfolio focussed on liver disease. I have over 16 years’ experience in Biomedical Research, out of which 12 are in the pharmaceutical industry. I have published fifteen scientific papers and am co-inventor on several method and composition of matter patent applications. I also have extended my contribution outside of our anti-viral department by applying my knowledge of the biological field as well as my managerial skills – these have contributed directly to the establishment of a Biotherapeutic department at Sandwich, and to the development of our external strategy for the New Opportunity department.
1998 - 2011Associate Research Fellow in the Internal Medicine Unit at Pfizer. As an experienced senior manager and drug discovery and development scientist, I am currently responsible for all activities associated with a key biological pre-clinical projects aimed at curing Hepatitis C Viral infection after a single injection with gene therapy. In my capacity as the Research Project Leader for this project, I lead a worldwide team to deliver a proof of concept study (the first patients are scheduled for 2011). During this process, we have received scientific advice and had close interaction with the FDA, and many other regulatory authorities around the world. In addition, as part of the leadership team, I have more recently been responsible for delivering a focused portfolio (including science, confidence in rationale, safety and other aspects) on various projects.
Furthermore, I have recent experience with antibody and small molecule preclinical and early human clinical trials, and have also worked in the area of HIV and HCV drug discovery.
I am a co-inventor of several patents and have been a key member of ideas-generating teams for many disease areas. I am also a co-author of a number of papers.