Dominique Bonafoux

- Project leader (R&D medicinal chemistry)
- Manager of multidisciplinary teams
- Member of the comity in charge of evaluating new therapeutic targets to maintain a strong R&D pipeline

- Evaluation the drugability of cytokine related projects in early discovery.
- Responsible for the discovery of novel inhibitors of TGF-b receptor 1, with improved pharmacokinetic profiles, for the treatment of fibrosis.
- Manager of a research associate.

- Design and synthesis of new drug candidates for the treatment of inflammatory disorders and hypertension. Optimization of their PK/ADME properties.
- Responsible for reviewing and assessing the metabolic stability/liability and potential toxicity of various structural fragments to support efficient drug discovery practices.